Tretinoin Microsphere Gel 0.1% (15g) combines the strongest strength with microsphere time-release technology, aiming to deliver powerful skin renewal with less of the irritation a conventional 0.1% gel can cause. It's intended for experienced users. It contains the same active ingredient (tretinoin) at 0.1% as Retin-A®. Often searched as "retinol," this is pharmaceutical-strength tretinoin — a stronger prescription retinoid, not cosmetic retinol.
Tretinoin Microsphere Gel and Retin-A are separately manufactured products. Their inactive ingredients, complete formulations, manufacturers, packaging, and regulatory status may differ.
Experienced users who want maximum strength but prefer a slow-release delivery. New users should start at a lower strength such as 0.025%.
At maximum strength with gradual release, tretinoin strongly supports skin renewal, which may help with the look of persistent acne-prone skin, texture, and signs of aging — designed to be gentler than a conventional 0.1% gel, though irritation is still possible.
Apply a thin layer at night to clean, dry skin, no more than every other night to begin, only once accustomed to lower strengths. Buffer with moisturizer if needed; always use SPF in the morning.
Even with slow release, 0.1% can bring dryness and sensitivity. Reduce frequency if needed. Visible change may take several weeks to a few months, and individual results vary.
For external use only. Not recommended during pregnancy or breastfeeding. This is maximum strength — introduce slowly, avoid layering other strong actives, and use a broad-spectrum SPF every morning, as tretinoin increases sun sensitivity. Patch-test first, avoid broken or sunburned skin, and stop use if significant irritation occurs. Use only as directed and consult a qualified professional if unsure.
Serving customers since 2011 · sourced from licensed manufacturers · free U.S. shipping on orders over $99 (shipping available to Canada) · fast dispatch · fresh, long-dated stock.
Can beginners use this? No — start at a lower strength and work up.
Why microsphere at 0.1%? The slow release aims to make the strongest strength more tolerable; experience varies.
How is this different from Retin-A? Same active ingredient and strength; separately manufactured (see disclaimer above).